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Does erythropoietin require iron to work? At this point iron is needed for the production of new hemoglobin. Erythropoietin promotes the maturation of BFU-E's into CFU-E's and subsequently into mature erythrocytes. If erythropoietin is present without sufficient iron, there is insufficient fuel for red cell production.
What do EPO injections do? Epoetin injection is a man-made version of human erythropoietin (EPO). EPO is produced naturally in the body, mostly by the kidneys. It stimulates the bone marrow to produce red blood cells. If the body does not produce enough EPO, severe anemia can occur.
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