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Why does melatonin give me restless legs? The naturally occurring hormone melatonin regulates your body's internal clock, or circadian rhythms. Its levels typically increase at night and taper off toward daybreak. Melatonin also inhibits the secretion of dopamine, which makes it bad news for restless legs syndrome patients.
Does mirtazapine help restless legs? OBJECTIVE: Mirtazapine is known to often provoke restless legs syndrome (RLS). Concomitant medication with tramadol, non-opioid analgesics, antihistamine, and dopamine-blocking agents was more frequently prescribed in subjects developing mirtazapine -associated RLS.
Is there an alternative to pramipexole for restless legs? Dopamine agonists such as pramipexole and ropinirole reduce symptoms in patients with restless legs syndrome (RLS). No benefit was noted with lower-dose pramipexole.
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